Solved!

It was Rosetta missing on my Ventura macOS.
I thought it would be installed automatically, but that did not seem to be the case here.

I have been using Helicon Focus for many years and never had any problems, but now I have a "new" MacBook Pro (2023, M2 Max, Ventura 13.7.4) and when I open Helicon Focus, I only get the error message "Helicon Focus quit unexpectedly".

A restart of the computer doesn't solve this.
What's going on ...