If you have a way to plug an I2C device into a computer (e. g. I2C to serial USB converter), it may work, although it may not be detected by Helicon Remote at first - depending on what name this device will report to the OS.
This is an older controller, if you want hassle-free out-of-the-box experience, get TMCM-1141 instead, it has onboard USB interface.